Tyrosinase Inhibitors from Natural and Synthetic Sources as Skin-lightening Agents

Natural peptides and proteins: potent tyrosinase inhibitors

Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...

Systemic skin whitening/lightening agents: what is the evidence?

The human skin color is one of the most perceptible phenotypic variations among humans and is determined primarily by the type and amount of melanin synthesized within melanosomes and the pattern of melanosome distribution within the melanocytes. Getting a lighter skin tone always draws a lot of interest, as for centuries, fair or light skin color has been a symbol of prominence, superiority an...

Natural Products as Sources of Antitumor Agents

Bacterial efflux pump inhibitors from natural sources.

The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia c...

Anticancer agents from diverse natural sources.

This review attempts to portray the discovery and development of anticancer agents/drugs from diverse natural sources. Natural molecules from these natural sources including plants, microbes and marine organisms have been the basis of treatment of human diseases since the ancient times. Compounds derived from nature have been important sources of new drugs and also serve as templates for synthe...